Anti-inflammatory activity of different extracts from Laurus nobilis growing in Algeria

R. Guedouari, M. Nabiev

Abstract


Abstract: Laurus nobilis was a common plant raised in Algeria and various researches were confirmed the medicinal potential of this plant. Some studies were focused on the antioxidant and antimicrobial properties of this plant but no studies were performed to determine its anti-inflammatory activity in vivo. Thus, the present study was carried out to study and compare the anti-inflammatory effect of the ethanolic extract of leaves with that of the fixed oil extracted from the fruits of Laurus nobilis. For our experiment, male BALB / c mice (n = 40) weighing 20 ± 1.0 g at 8 weeks old were divided into four treatment groups (10 mice / group): (a) control, (b) extract fruit (fixed oil), (c) leaf extract (ethanolic extract 100 mg / kg) and (d) reference (Diclofenac 50 mg). These mice were housed under standard environmental conditions. Anti-inflammatory capacity was evaluated by hind paw oedema model using carrageenan-induced inflammation in mice. The ethanolic leaf extract reduced the increase in the volume of the paw with a percentage inhibition of 30.62% (p <0.05), this percentage was found to be 26.33% (p <0.05 ) with fixed oil from Laurus nobilis fruit, while the activity of Diclofenac was 17.59% (p <0.05). In conclusion, the importance of Laurus nobilis lay in their fixed oil and their ethanolic extract which could be used scientifically in the treatment of inflammation. A phytochemical screening of the leaves and fruits of Laurus nobilis showed the presence of flavonoids and saponins which may be at the origin of the anti-inflammatory properties of the extract. The total phenolic in the leaf extract of  Laurus nobilis  was  37,72±0,336 μg GAE /mg of dry extract.

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References


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